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Xq28 is a chromosome pack and genetic marker situated at the tip of the X chromosome which has been studied since at least The study by Hamer et al. This pattern of inheritance suggested that there might be linked genes on the X chromosome , since males everlastingly inherit their copy of the X chromosome from their mothers.
Polymorphisms of genetic markers of the X chromosome were analyzed for 40 families to see if a predetermined marker was shared nigh a disproportionate amount of brothers who were both gay.
The results showed that among gay brothers, the concordance rate during markers from the Xq28 region were significantly greater than expected for occasional Mendelian segregation, indicating that a link did remain in that small cross-section.
It was concluded that at least one ritual of male homosexuality is preferentially transmitted through the maternal side and is genetically linked to the Xq28 region.
A support study, Hu et al. This study also included heterosexual brothers, who showed significantly less than expected sharing of the Xq28 region, as expected into a genetic locus that in one form is associated with same-sex appeal and in another put up is associated with opposite-sex attraction. In this retreat no link to Xq28 was found among faggy females, indicating a conflicting genetic pathway as in the direction of most sex-specific phenotypes.
Hamer's findings were highlighted in scientific journals including Proficiency ,  Nature  and the topic of a mini-symposium in Well-regulated American.
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A pride march in Belgrade last month. Indeed, over the past 2 decades, researchers have turned up considerable evidence that homosexuality isn't a lifestyle choice, but is rooted in a person's biology and at least in part determined by genetics.
A new study of male twins, scheduled for presentation at the annual meeting of the American Society of Human Genetics ASHG in Baltimore, Maryland, today, could help explain that paradox. It finds that epigenetic effects, chemical modifications of the human genome that alter gene activity without changing the DNA sequence, may have a major influence on sexual orientation.
But Rice and others caution that the research is still preliminary and based on a small sample. The discovery generated worldwide headlines, but some teams were unable to replicate the findings and the actual genes have not been found—not even by a team that vindicated Hamer's identification of Xq28 in a sample size 10 times larger than his last year. Twin studies suggested, moreover, that gene sequences can't be the full explanation.
That's why some have suggested that epigenetics—instead of or in addition to traditional genetics—might be involved. During development, chromosomes are subject to chemical changes that don't affect the nucleotide sequence but can turn genes on or off; the best known example is methylation, in which a methyl group is attached to specific DNA regions.
Recent studies, however, have shown that some marks are passed on to the next generation. In a paper, Rice and his colleagues suggested that such unerased epi-marks might lead to homosexuality when they are passed on from father to daughter or from mother to son.
Such ideas inspired Tuck Ngun, a postdoc in Vilain's lab , to study the methylation patterns at , regions in the DNA of 37 pairs of male identical twins who were discordant—meaning that one was gay and the other straight—and 10 pairs who were both gay.
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- Two gene variants have been found to be more common in gay men, adding to mounting evidence that sexual orientation is at least partly biologically determined. We have known for decades that sexual orientation is partly heritable in men, thanks to studies of families in which some. (Female homosexuality is also heritable but less is known of the genetic however, because their second X-chromosome masks the mutated gene.
- The study analysed the genetic code of gay men to find common genetic markers, but scientists say it's a far cry from finding the 'gay gene'. Most scientists agree that it is unlikely that there is a single "gay gene" that 17, — A genetic study on the courtship behavior of mutant fruit flies may.
- If a so-called "gay gene," exists, what is the evolutionary logic behind it? simple gay gene exists "as a kind of mutation" is downright ludicrous.
- Homosexuality may be caused by chemical modifications to DNA | Science | AAAS
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- Xq28 - Wikipedia
Valentine's Day unofficial?The study analysed the genetic code of gay men to find common genetic markers, but scientists say it's a far cry from finding the 'gay gene'. Most scientists agree that it is unlikely that there is a single "gay gene" that 17, — A genetic study on the courtship behavior of mutant fruit flies may..
Is there a gay gene? - Tomorrow's World - BBC
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